| Bioactivity | BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2]. |
| Invitro | BPIQ-I (0-50 µM; 3 days) 具有抗增殖活性，对 A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 细胞的 EC50 值分别为 >50、30、>50、6.5、>50 µM [1].BPIQ-I (10 nM) 通过与 ATP 竞争来阻断 erbB RTK，从而消除 CO2 敏感性[2]。 Cell Viability Assay [1] Cell Line: |
| Name | BPIQ-I |
| CAS | 174709-30-9 |
| Formula | C16H12BrN5 |
| Molar Mass | 354.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107. [2]. Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67. |