| Bioactivity | GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC[1]. | ||||||||||||
| In Vivo | GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CLhep = 17 and 42 mL/min/kg, respectively) [1]. | ||||||||||||
| Name | GNE-6468 | ||||||||||||
| CAS | 1677668-27-7 | ||||||||||||
| Formula | C23H16ClN3O4 | ||||||||||||
| Molar Mass | 433.84 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12. |
GNE-6468
CAS: 1677668-27-7 F: C23H16ClN3O4 W: 433.84
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE
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