| Bioactivity | Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1 interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77 µM[1]. | ||||||||||||
| Name | Complement C5-IN-1 | ||||||||||||
| CAS | 2365402-67-9 | ||||||||||||
| Formula | C24H32N2O6 | ||||||||||||
| Molar Mass | 444.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Jendza K, et al. A small-molecule inhibitor of C5 complement protein. Nat Chem Biol. 2019 Jul;15(7):666-668. |
Complement C5-IN-1
CAS: 2365402-67-9 F: C24H32N2O6 W: 444.52
Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1
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