| Bioactivity | GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM)[1]. |
| In Vivo | GNE-2256 (3 mg/kg) shows inhibition of IL-6, TNFα, and IFNα secretion in R848-induced mouse PD model[1]. |
| Name | GNE-2256 |
| CAS | 2102170-43-2 |
| Formula | C24H27FN6O4 |
| Molar Mass | 482.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rajapaksa NS, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett. 2019 Nov 11;11(3):327-333. |
GNE-2256
CAS: 2102170-43-2 F: C24H27FN6O4 W: 482.51
GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM
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