COX-2-IN-26_product_DataBase

Bioactivity	COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].
Invitro	COX-2-IN-26 (compound 16) shows significant COX-2 selectivity with an SI value of 158.36[1].
In Vivo	COX-2-IN-26 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively[1]..COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats[1].
Name	COX-2-IN-26
CAS	2413565-19-0
Formula	C23H21N7OS3
Molar Mass	507.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

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