| Bioactivity | GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1]. |
| Target | Gastrin releasing peptide receptor (GRPR) |
| Name | GB-6 |
| CAS | 2413262-74-3 |
| Sequence | Gln-{Htp}-{β-Ala}-{Nva}-Gly-His-NH2 |
| Shortening | Q-{Htp}-{β-Ala}-{Nva}-GH-NH2 |
| Formula | C32H45N11O8 |
| Molar Mass | 711.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tu Y, et al. Novel GRPR-Targeting Peptide for Pancreatic Cancer Molecular Imaging in Orthotopic and Liver Metastasis Mouse Models. Anal Chem. 2023 Aug 1;95(30):11429-11439. |