Bioactivity | Fedovapagon (VA106483) is a selective and orally active vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM. Fedovapagon can be used in the research of nocturia[1]. |
In Vivo | Fedovapagon (1 mg/kg, oral administration) inhibits urine output with 81% inhibition rate in rats[1]. Animal Model: |
Name | Fedovapagon |
CAS | 347887-36-9 |
Formula | C27H34N4O3 |
Molar Mass | 462.58 |
Appearance | Solid |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
Reference | [1]. Yea CM, et al. New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem. 2008 Dec 25;51(24):8124-34. |