| Bioactivity | Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1]. |
| Target | IC50: 3.71 μM (human purified FASN activity) |
| Invitro | Fasnall 有效阻断乙酸盐和葡萄糖掺入总脂质中，在 HepG2 细胞中的 IC50 值分别为 147 和 213 nM[1]。Fasnall（50 μM；24-120 小时）抑制乳腺癌细胞系的增殖[1]。Fasnall（25-100 μM；24 小时）诱导 HER2+ 乳腺癌细胞系凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Fasnall（15 mg/kg，腹腔注射，每周两次；3 周）在 HER2+ 乳腺癌的 MMTV-Neu 模型中显示出有效的抗肿瘤活性[1]。 Animal Model: |
| Name | Fasnall |
| CAS | 929978-58-5 |
| Formula | C19H22N4S |
| Molar Mass | 338.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yazan Alwarawrah, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88. |