| Bioactivity | FXR agonist 10 (Compound 27) is an agonist for FXR with an EC50 of 14.26 μM. FXR agonist 10 upregulates the expression of SHP and BSEP proteins, downregulates the expression of NTCP and CYP7A1 proteins. FXR agonist 10 ameliorates the ANIT-induced cholestasis in mouse model[1]. |
| Target | EC50: FXR (14.26 μM) |
| Formula | C15H22O4 |
| Molar Mass | 266.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yao Z, et al., The discovery of a new potent FXR agonist based on natural product screening. Bioorg Chem. 2024 Feb;143:106979. |