| Bioactivity | FXIIa-IN-3 (Compound 8) is a potent and selective Factor XIIa (FXIIa) inhibitor, with an IC50 of 0.045 μM. FXIIa-IN-3 also exhibits a substantial margin of selectivity against related serine proteases, including FXIa, FXa, and FIXa. FXIIa-IN-3 can be used for the research of thromboembolic diseases[1]. |
| Target | 0.045 μM (FXIIa), 14.9 μM (FXIa), 47.6 μM (FXa), 0.019 μM (Thrombin) |
| Formula | C14H16N4O6 |
| Molar Mass | 336.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Woodland M L D, et al. New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants. ACS Omega. 2024. |