Avenanthramide-C methyl ester_product_DataBase

Bioactivity	Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity[1].
Invitro	Avenanthramide-C methyl ester (40, 100 μM; 24 h) 可剂量依赖性地降低内皮细胞 (HAEC) 中的 mRNA 表达以及 IL-6、IL-8 和 MCP-1 的分泌[1]。抑制 IL-1β 和 TNFα 刺激的 NF-κB 激活[1]。Avenanthramide-C methyl ester (1-100 μM; 24 h) 抑制由 TNFR 相关因子 2 和 6（TRAF2、TRAF6）以及 NFκB 诱导激酶 (NIK) 激活的 NFκB 依赖性报告基因表达[1]。Avenanthramide-C methyl ester 还剂量依赖性地降低 IκB 激酶 (IKK) 和 IκB 的磷酸化水平，并通过蛋白质印迹测量阻止 IκB 降解[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Avenanthramide-C methyl ester 相关抗体: Western Blot Analysis[1] Cell Line:
CAS	955382-52-2
Formula	C17H15NO6
Molar Mass	329.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Guo W, et al. Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells. Free Radic Biol Med. 2008 Feb 1;44(3):415-29.

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