| Bioactivity | FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1]. |
| Target | β-lactamase |
| Invitro | FPI-1523 inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1].FPI-1523 inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1]. 0 --> FPI-1523 相关抗体: |
| Name | FPI-1523 |
| CAS | 1452459-50-5 |
| Formula | C9H14N4O7S |
| Molar Mass | 322.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8. |