Bioactivity | FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2]. | |||||||||
Invitro | FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively[1]. | |||||||||
Name | FPA-124 | |||||||||
CAS | 902779-59-3 | |||||||||
Formula | C11H9Cl2CuN3O2S | |||||||||
Molar Mass | 381.73 | |||||||||
Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
Storage |
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