AZT triphosphate tetraammonium_product_DataBase

Bioactivity	AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway[1][2][3].
Invitro	AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium 通过用 100 µM Zidovudine (AZT) 处理 48 小时进行积累破坏 H9c2 细胞中的线粒体管状网络。 AZT triphosphate tetraammonium 积累导致 Opa1 的下调和 Drp1 的上调。 AZT triphosphate tetraammonium 导致大鼠胚胎成肌细胞 H9c2 细胞模型线粒体功能障碍，增加细胞毒性活性氧 (ROS) 的产生，并损害线粒体质量控制系统的平衡[1]。
Name	AZT triphosphate tetraammonium
Formula	C10H28N9O13P3
Molar Mass	575.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

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