| Bioactivity | FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3]. |
| Invitro | FP-biotin has good reactivity with human AChE and BChE despite its large biotin group. FP-biotin is suitable for the proposed task of identifying organophosphorus toxicants reactive proteins[1]. |
| Name | FP-Biotin |
| CAS | 259270-28-5 |
| Formula | C27H50FN4O5PS |
| Molar Mass | 592.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18(4):747-754. [2]. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861. [3]. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498. |
FP-Biotin
CAS: 259270-28-5 F: C27H50FN4O5PS W: 592.75
FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxica
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