| Bioactivity | AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 63.2 nM[1]. |
| Invitro | AMG8788 potently inhibits the menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8, the plasma half-life (T1/2) in rats is 6.7 h[1]. |
| In Vivo | AMG8788 (30 mg/kg; p.o.; once) elicits a transient decrease in body temperature (Tb) in rats[1]. Animal Model: |
| Name | AMG8788 |
| CAS | 1159996-43-6 |
| Formula | C23H18F4N2O |
| Molar Mass | 414.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gavva NR, et al. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain. 2012 May 9;8:36. |