| Bioactivity | FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. |
| Invitro | FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1]. |
| Name | FM-479 |
| CAS | 2226521-64-6 |
| Formula | C25H26N6O2 |
| Molar Mass | 442.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. https://www.thesgc.org/chemical-probes/FM-381 |