| Bioactivity | FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase[1]. | ||||||||||||
| Invitro | FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4)[2].FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells[3]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | FIN56 | ||||||||||||
| CAS | 1083162-61-1 | ||||||||||||
| Formula | C25H31N3O5S2 | ||||||||||||
| Molar Mass | 517.66 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kenichi Shimada, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503. [2]. Yangchun Xie, et al. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017 Aug 15;20(7):1692-1704. [3]. Michael M Gaschler, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. |