DLin-KC2-DMA_product_DataBase

Bioactivity	DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies[1][2].
Invitro	DLin-KC2-DMA (1, 5 μg; 72 h) effectively produces a significant siRNA-mediated GAPDH gene silencing in both macrophages and dendritic cells[1].DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells[1].DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway[1].DLin-KC2-DMA displays almost no toxicity in primary APCs[1]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	DLin-KC2-DMA contained-LNP siRNA systems (5 mg/kg; i.v.; single) effectively silences target genes in APcs in vivo[1]. Animal Model:
Name	DLin-KC2-DMA
CAS	1190197-97-7
Formula	C43H79NO2
Molar Mass	642.09
Appearance	Liquid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, stored under nitrogen *该产品在溶液状态不稳定，建议您现用现配，即刻使用。
Reference	[1]. Basha G, et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther. 2011 Dec;19(12):2186-200. [2]. Miller AD, et al. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

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