| Bioactivity | FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1]. | ||||||||||||
| Target | IC50: 0.43 μM (human FATP1).IC50: 0.39 μM (mouse FATP1) | ||||||||||||
| In Vivo | FATP1-IN-2 (10 mg/kg; p.o.) shows a Cmax value above the mouse IC50 value[1].FATP1-IN-2 (3, 10, 30 mg/kg; p.o.; 4 weeks) shows TG content of each tissue does not change at any dose[1]. Animal Model: | ||||||||||||
| Name | FATP1-IN-2 | ||||||||||||
| CAS | 2650944-83-3 | ||||||||||||
| Formula | C19H20FN5O | ||||||||||||
| Molar Mass | 353.39 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565. |
FATP1-IN-2
CAS: 2650944-83-3 F: C19H20FN5O W: 353.39
FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhi
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