| Bioactivity | FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide, with the Kd of 180-560 nM. FAM-DEALA-Hyp-YIPD can be used to assess VHL binding in Fluorescence Polarization (FP) displacement assay, and evaluate the effect of VHL binding on degradation activity[1]. |
| Name | FAM-DEALA-Hyp-YIPD |
| Sequence | {FAM}-Asp-Glu-Ala-Leu-Ala-{Hyp}-Tyr-Ile-Pro-Asp |
| Shortening | {FAM}-DEALA-{Hyp}-YIPD |
| Formula | C71H84N10O25 |
| Molar Mass | 1477.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Buckley DL, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc. 2012;134(10):4465-4468. |