| Bioactivity | Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that can reduce the phosphorylation of NF-κB p65 and has anti-inflammatory properties. Euphjatrophane M can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in RAW 264.7 macrophages induced by lipopolysaccharide (LPS, HY-D1056)[1]. |
| Formula | C20H28O4 |
| Molar Mass | 332.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ying Yan, et al. Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity. Bioorg Chem. 2024 Nov 22:154:107989. |