| Bioactivity | Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC50 value of 0.1 nM[1]. |
| Target | IC50: 0.437 nM (ERR α in MCF-7 cells) |
| Name | Estrogen receptor modulator 8 |
| CAS | 2170766-56-8 |
| Formula | C25H24F4N2O2 |
| Molar Mass | 460.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04. |
Estrogen receptor modulator 8
CAS: 2170766-56-8 F: C25H24F4N2O2 W: 460.46
Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF
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