Edonentan hydrate_product_DataBase

Bioactivity	Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the endothelin A (ETA) receptor, with a Ki of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility[1].
In Vivo	Edonentan (3-10 µmol/kg，口服)可阻断大的 ET-1 升压反应[1]。与 BMS-193884 (HY-19263) 相比，Edonentan (BMS 207940) 显示出改善的全身清除率 (Cl) 和稳态分布容积 (Vss)[1]。
Name	Edonentan hydrate
CAS	264609-13-4
Formula	C28H34N4O6S
Molar Mass	554.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003 Jan 2;46(1):125-37.

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