| Bioactivity | ERRγ agonist-1 is a potent ERRγ agonist. ERRγ agonist-1 increases transcriptional activities of ERRγ. ERRγ agonist-1 has the potential for the research of neuropsychological disorders[1]. |
| Invitro | ERRγ agonist-1 (compound 5d) (5 µM; 3 days) significantly increases the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT), DAergic neuronal phenotypes (dopaminergic neuronal phenotype) in neuroblastoma SH-SY5Y cells[1].ERRγ agonist-1 (5 µM; 3 days) induces DAergic neuronal phenotypes via the ERRγ-mediated up-regulation of CREB-signaling pathway[1]. Western Blot Analysis[1] Cell Line: |
| Name | ERRγ agonist-1 |
| Formula | C17H21N5O |
| Molar Mass | 311.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim T, et al. Discovery of new ERRγ agonists regulating dopaminergic neuronal phenotype in SH-SY5Y cells. Bioorg Chem. 2022; 122:105716. |