| Bioactivity | ERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC50 of 10.5 μM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H2O2-induced cardiomyocyte death and Ang II (HY-13948)-induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models[1]. |
| CAS | 930856-19-2 |
| Formula | C24H25N3O2S |
| Molar Mass | 419.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cools JMT, et al., Small-molecule-induced ERBB4 activation to treat heart failure. Nat Commun. 2025 Jan 10;16(1):576. |
ERBB agonist-1
CAS: 930856-19-2 F: C24H25N3O2S W: 419.54
ERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerizat
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