| Bioactivity | ER degrader 4 is a selective and orally active estrogen receptor degrader. ER degrader 4 has anti-tumor activity[1]. |
| Invitro | ER degrader 4 (Compound 22h) 抑制 MCF-7 细胞增殖，IC50 为 0.20 μM[1]。ER degrader 4 (1 nM-10 μM，24 小时) 剂量依赖性地降解 MCF-7 细胞中的 ER[1]。ER degrader 4 (10 μM, 24 h) 降低 MCF-7 细胞中 GREB1、PGR 和 TFF1 的基因表达水平[1]。ER degrader 4 (10 μM, 24 h) 在 G0/G1 期阻止 MCF-7 细胞[1]。 Western Blot Analysis[7] Cell Line: |
| In Vivo | ER degrader 4 (化合物 22h) (30 mg/kg，灌胃) 抑制 MCF-7 异种移植模型中的肿瘤生长[1]。 Animal Model: |
| Name | ER degrader 4 |
| CAS | 2913192-39-7 |
| Formula | C26H19FO4S |
| Molar Mass | 446.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xie YQ, et al. Design, synthesis and structure-activity relationship of novel oxime ether strobilurin derivatives containing substituted benzofurans. Pest Manag Sci. 2015 Mar;71(3):404-14. |