| Bioactivity | EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B)[1]. |
| Invitro | EM-163 (50-100 μg/mL) 可以靶向 TIR 结构域，能与 TIR 结构域的蛋白结合且可以抑制 TIR-TIR 结构域的相互作用[1]。EM-163 (10-500 μM; 30 min) 在人类单核细胞 (MNS) 中抑制了 SEB (200 ng/mL) 诱导的 TNF-α、IFN-γ、IL-2 和 IL-1b 的产生[1]。 0 --> EM-163 相关抗体: |
| In Vivo | EM-163 (0.21-0.86 mg/mouse; 腹腔注射; 单剂量) 能够有效抑制促炎细胞因子的释放，延迟或避免葡萄球菌肠毒素 B (SEB) 对 BALB/c 小鼠引起的中毒性休克导致的死亡[1]。 Animal Model: |
| Name | EM-163 |
| CAS | 1206480-93-4 |
| Formula | C44H60IN5O4 |
| Molar Mass | 849.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kissner TL, et al. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One. 2012;7(7):e40773. |