PeptideDB

ELOVL6-IN-2

CAS: 1067647-43-1 F: C28H23F6N3O4 W: 579.49

ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, wit
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Bioactivity ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM[1].
Target IC50: 34 nM (ELOVL6)
In Vivo ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver[1].ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable[1].ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure[1]. Animal Model:
Name ELOVL6-IN-2
CAS 1067647-43-1
Formula C28H23F6N3O4
Molar Mass 579.49
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. akahashi T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145.