| Bioactivity | EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase[1]. |
| Target | EGFRC797S |
| Name | EGFR-IN-78 |
| Formula | C23H32BrN7O2S |
| Molar Mass | 550.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mao YZ, et al. Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2023 Jul 15;91:129381. |