| Bioactivity | VEGFR-2-IN-45 (compound 7c) is a potent inhibitor of EGFRt790m and EGFRWT with IC50s of 0.08 µM, and 0.13 µM, respectively. VEGFR-2-IN-45 also inhibits PI3K-δ with the IC50 of 0.64 µM[1]. |
| CAS | 101578-13-6 |
| Formula | C17H21N3O |
| Molar Mass | 283.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nada Reda, et al. Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis, biological Evaluation, and docking studies. Bioorg Chem. 2024 Apr:145:107185. |