| Bioactivity | AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway[1]. |
| Invitro | AACA (10 μM，12 h) 可以激活被骨硬质蛋白抑制的 Wnt 信号通路，上调骨形成标志物的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AACA 相关抗体: Real Time qPCR[1] Cell Line: |
| CAS | 2515609-54-6 |
| Formula | C14H14N2O4 |
| Molar Mass | 274.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu S, et al., Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design. Eur J Med Chem. 2024 Apr 16;271:116414. |