| Bioactivity | Dox-btn2 is a biotinylated derivative of Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm[1]. |
| Invitro | Dox-btn2 (1 μM；6 h；Exc=531/40 nm，Emi=593/40 nm) 在 U2OS 细胞中显示可视化，帮助绘制定位与 DNA 和染色质蛋白相互作用的原位图谱[1]。 |
| Name | Dox-btn2 |
| Formula | C48H64N4O18S |
| Molar Mass | 1017.10 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Yu Z, et al. Chem-map profiles drug binding to chromatin in cells. Nat Biotechnol. 2023 Jan 23. |