Allisartan isoproxil

CAS: 947331-05-7 F: C27H29ClN6O5 W: 553.01

Allisartan isoproxil (ALS-3) is an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1. Allisartan

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Bioactivity	Allisartan isoproxil (ALS-3) is an orally potent, selective, non-peptide inhibitor of Angiotensin II Type 1. Allisartan isoproxil is also an antihypertensive agent. Allisartan isoproxil may inhibit angiotensin-aldosterone system and oxidative stress. Allisartan isoproxil lowers blood pressure and protects the organs, preventing cerebrovascular damage. Allisartan isoproxil (80-320 mg/kg/d) has shown toxicity in rat models by targeting liver organs[1][2].
In Vivo	Allisartan isoproxil 的代谢途径相对简单，Allisartan isoproxil 在胃肠道吸收过程中通过酯酶完全直接转化为EXP-3174[1]。Allisartan isoproxil (20、80和320 mg/kg；口服；26 周) 在 80-320 mg/kg/天的剂量下，会减轻 Sprague-Dawley 大鼠的体重[1]。Allisartan isoproxil (30mg /kg/天；口服；55 周) 显著降低卒中易感肾血管性高血压大鼠 (RHR-SP) 的相关死亡，延长寿命[2]。 Animal Model:
Name	Allisartan isoproxil
CAS	947331-05-7
Formula	C27H29ClN6O5
Molar Mass	553.01
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Liu Y, et al. A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats. Drug Chem Toxicol. 2013 Oct;36(4):443-50. [2]. Ling QS, et al. Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage. Acta Pharmacol Sin. 2021 Jun;42(6):871-884.

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