| Bioactivity | Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm[1][2][3]. |
| Name | Divin |
| CAS | 1443321-11-6 |
| Formula | C22H20N4O2 |
| Molar Mass | 372.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maoquan Zhou, et al. Structure-activity studies of divin: an inhibitor of bacterial cell division. ACS Med Chem Lett. 2013 Sep 12;4(9):880-885. [2]. Ye-Jin Eun, et al. Divin: a small molecule inhibitor of bacterial divisome assembly. J Am Chem Soc. 2013 Jul 3;135(26):9768-76. [3]. Thiago M A Santos, et al. Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis. ACS Chem Biol. 2018 Jan 19;13(1):235-246. |
Divin
CAS: 1443321-11-6 F: C22H20N4O2 W: 372.42
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-ne
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