| Bioactivity | Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. | ||||||||||||
| Invitro | In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[3]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[1]. | ||||||||||||
| Name | Diosgenin | ||||||||||||
| CAS | 512-04-9 | ||||||||||||
| Formula | C27H42O3 | ||||||||||||
| Molar Mass | 414.62 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|