| Bioactivity | Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2]. | ||||||||||||
| Invitro | Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin were 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively[3]. Cell Cytotoxicity Assay[2] Cell Line: | ||||||||||||
| Name | Tubercidin | ||||||||||||
| CAS | 69-33-0 | ||||||||||||
| Formula | C11H14N4O4 | ||||||||||||
| Molar Mass | 266.25 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|