| Bioactivity | Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1]. |
| In Vivo | Delapril (5-20 mg/kg，饮用水喂养) 可减缓胆固醇喂养兔的动脉粥样硬化进展[2]。Delapril (1-10 mg/kg，p.o.，每日一次，持续 5 周) 在高血压大鼠中表现出自发的抗高血压作用[3]。 Animal Model: |
| Name | Delapril |
| CAS | 83435-66-9 |
| Formula | C26H32N2O5 |
| Molar Mass | 452.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43(3):242-9. [2]. Hernandez A,et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137(1):71-6. [3]. Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42(1):1-8. |