Dehydrobruceine B_product_DataBase

Bioactivity	Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2[1].
Invitro	Dehydrobruceine B (1 μM; 48 h) 和 Cisplatin (3-18 μM; 48 h) 在 A549 细胞中具有协同作用，致使细胞毒性和凋亡效应[1]。Dehydrobruceine B (1 μM; 24 h) 在 Cisplatin (3 μM, 6 μM; 24 h) 处理的A549细胞中，诱导胞内 ROS 产生[1]。Dehydrobruceine B (3 μM, 6 μM; 24 h) 在 Cisplatin (3 μM, 6 μM; 24 h) 处理的A549细胞中，促进线粒体膜电位 (MMP) 的去极化和细胞色素 c 的易位[1]。Dehydrobruceine B (1 μM; 24 h) 增强 A549 细胞抗凋亡和促凋亡蛋白水平的变化[1]。 Western Blot Analysis[1] Cell Line:
Name	Dehydrobruceine B
CAS	53730-90-8
Formula	C23H26O11
Molar Mass	478.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB