| Bioactivity | DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1]. | ||||||||||||
| Target | IC50: 1.6 μM (MTHFD2), >30 μM (MTHFD1). | ||||||||||||
| Name | DS44960156 | ||||||||||||
| CAS | 2361327-08-2 | ||||||||||||
| Formula | C20H15NO5 | ||||||||||||
| Molar Mass | 349.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898. |