| Bioactivity | DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 (DNA Lig1) inhibitor, which inhibits DNA ligation and disrupts Lig I’s DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells[1]. |
| Name | DNA relaxation-IN-1 |
| CAS | 2190506-29-5 |
| Formula | C30H27N3O2S |
| Molar Mass | 493.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maurya P, et al. Synergy between human DNA ligase I and topoisomerase 1 unveils new therapeutic strategy for the management of colorectal cancer. J Biomol Struct Dyn. 2024 Jan 5:1-16. |
DNA relaxation-IN-1
CAS: 2190506-29-5 F: C30H27N3O2S W: 493.62
DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 (DNA Lig1) inhibitor, which inhibits DNA ligation and disrupts Lig I
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