| Bioactivity | DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1]. |
| Invitro | DCN1-UBC12-IN-2 (DN-2) possesses relatively low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 27.34 μM for 24 h. |
| Name | DCN1-UBC12-IN-2 |
| CAS | 2374827-47-9 |
| Formula | C23H20ClN7O3S2 |
| Molar Mass | 542.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190. |
DCN1-UBC12-IN-2
CAS: 2374827-47-9 F: C23H20ClN7O3S2 W: 542.03
DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.