| Bioactivity | CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1]. |
| Target | IC50: 8.6 nM (GRK5), 12 μM (GRK2). |
| Invitro | CCG-273463 (0.02-1 μM) potently and highly inhibits GRK5 (IC50: 8.6 nM), with inhibitory rate of 93% (GRK5) and 97% (GRK6) at 1 μM[1]. |
| Name | CCG-273463 |
| CAS | 2750413-99-9 |
| Formula | C26H25BrN4O3 |
| Molar Mass | 521.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rachel A Rowlands, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64(1):566-585. |
CCG-273463
CAS: 2750413-99-9 F: C26H25BrN4O3 W: 521.41
CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in th
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