| Bioactivity | DCN1-UBC12-IN-1 is potent and selective DCN1-UBC12 inhibitor with an IC50 of 2.86 nM. Anticardiac fibrotic effect[1]. |
| Invitro | DCN1-UBC12-IN-1 (compound 44) possesses low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 9.97 μM for 24 h[1]. |
| Name | DCN1-UBC12-IN-1 |
| CAS | 2374827-31-1 |
| Formula | C24H23N7O3S2 |
| Molar Mass | 521.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190. |
DCN1-UBC12-IN-1
CAS: 2374827-31-1 F: C24H23N7O3S2 W: 521.61
DCN1-UBC12-IN-1 is potent and selective DCN1-UBC12 inhibitor with an IC50 of 2.86 nM. Anticardiac fibrotic effect.
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