DC-BPi-11_product_DataBase

Bioactivity	DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation[1].
Target	698 nM (BPTF)
Invitro	DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1].DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1].DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1].DC-BPi-11 is safety and shows minimal effects on normal cells[1]. Western Blot Analysis[1] Cell Line:
Name	DC-BPi-11
CAS	2758411-61-7
Formula	C20H23N5O2S
Molar Mass	397.49
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lu T, et al. Discovery of High-Affinity Inhibitors of the BPTF Bromodomain. J Med Chem. 2021 Aug 26;64(16):12075-12088.

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