| Bioactivity | DBO-83 dihydrochloride is a novel nicotinic acetylcholine receptor agonist, and binds to nAChRs in rat cortical membranes with a Ki value of 4.1 nM. DBO-83 dihydrochloride shows antinociceptive and anti-amnesic activities[1][2][3]. |
| CAS | 195211-53-1 |
| Formula | C10H15Cl3N4 |
| Molar Mass | 297.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Barlocco D,et al. Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling. J Med Chem. 1998;41(5):674-681. [2]. Carla Ghelardini, et al. Antinociceptive profile of the new nicotinic agonist DBO-83. Drug development research. 40:,251-258.(1997) [3]. Carla Ghelardini, et al. Antiamnesic Activity of the Nicotinic Agonist DBO-83 in Mice.Drug development research. |
DBO-83 dihydrochloride
CAS: 195211-53-1 F: C10H15Cl3N4 W: 297.61
DBO-83 dihydrochloride is a novel nicotinic acetylcholine receptor agonist, and binds to nAChRs in rat cortical membrane
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