| Bioactivity | DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells[1]. |
| Invitro | DBI-2 抑制 LS174T 细胞和 HCT116 细胞增殖的 IC50 分别为 1.14 μM 和 0.53 μM[1]。DBI-2 (3 μM；24 小时) 通过激活 AMPK 并抑制 mTOR 和 Wnt 通路来诱导生长抑制[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DBI-2 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | DBI-2（40 mg/kg；腹腔注射；持续 12 天）可抑制结肠直肠癌 (CRC) 异种移植小鼠模型中的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2939087-00-8 |
| Formula | C24H29BrN2O3 |
| Molar Mass | 473.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lichao Guo, et al. Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells. Cancers (Basel). 2024 Apr 2;16(7):1399. |