BRD4 degrader-2

CAS: F: C34H33ClN6O4S W: 657.18

BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex

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Bioactivity	BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1][2].
Formula	C34H33ClN6O4S
Molar Mass	657.18
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Central Science. DOI: 10.1021/acscentsci.4c00286 [2]. Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9(5):915-926.