| Bioactivity | D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity[1]. |
| Name | D-Leu-Pro-Arg-Rh110-D-Pro |
| Sequence | {d-Leu}-Pro-Arg-{Rh110}-{d-Pro} |
| Shortening | {d-Leu}-PR-{Rh110}-{d-Pro} |
| Formula | C42H51N9O7 |
| Molar Mass | 793.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lorthiois E, et al. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 Aug 13;63(15):8088-8113. |
D-Leu-Pro-Arg-Rh110-D-Pro
CAS: F: C42H51N9O7 W: 793.91
D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consist
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