| Bioactivity | Cyprodime is a selective µ opioid receptor (MOR) antagonist with Kis of 5.4, 244.6, and 2187 nM for µ, δ, and κ, respectively[1]. |
| In Vivo | Cyprodime (0.003-1 mg/kg; i.v.) do not significantly change the control bladder capacity during repeated acetic acid (AA) cystometrogram (CMG) but significantly reduces tibial nerve stimulation (TNS) inhibition starting from the 0.1 mg/kg dose and completely eliminates the inhibition induced by both 2 T and 4 T TNS at doses of 0.3-1 mg/kg[2]. |
| Name | Cyprodime |
| CAS | 118111-54-9 |
| Formula | C22H29NO3 |
| Molar Mass | 355.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Márki A, et al. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. Eur J Pharmacol. 1999;383(2):209-214. [2]. Zhang Z, , et al. Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats. J Pharmacol Exp Ther. 2015;355(2):228-234. |